Each LED on the microbit can be identified by its x and y coordinates as shown on the image below:
To turn on and off the LEDs, use the plot and unplot blocks under the Led category of the Block Editor.
Turn on the specified LED using x and y coordinates (x is horizontal, y is vertical).
Turn off the specified LED using x and y coordinates (x is horizontal, y is vertical).
As an example, the following program will lit the central led at coordinates (2,2) then blink in a loop with a pause of 500 ms.
The next program blinks the middle LED from top to bottom in a loop.